With a long standing track record of success, GS-CHO based expression systems have become the most widely used platform for developing and manufacturing recombinant therapeutic proteins today. But the evolving demands of the biologics industry including pressures on timelines, COGs and the diversification of molecular formats means that ongoing innovation is required to ensure GS-CHO systems keep pace with industry needs. In this article we briefly summarise some of the latest approaches for improving the performance of GS-CHO expression systems, from DNA to cell line to data science.
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